Recombinant human factor VIIa (rFVIIa) can activate factor FIX on activated platelets
نویسندگان
چکیده
منابع مشابه
Factor VIIa-mediated tenase function on activated platelets under flow.
BACKGROUND Tissue factor (TF) and/or active factor (F)VIIa may be stored inside resting platelets. OBJECTIVES The objective of this study was to examine if platelets, following activation of GPVI, could support tenase and prothrombinase activity without any exogenously added tissue factor. METHODS Thrombin (IIa) formation on gel-filtered platelets with added factors or the clotting of plate...
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BACKGROUND The recombinant human coagulation FVIIa was approved for the treatment of bleeding in hemophilia patients. The reports of a good hemostatic effect were followed by studies and applications without a regulatory extension of the therapeutic indication (off-label use). The aim of this retrospective study is the evaluation of thromboembolic adverse events and side effects in a large coho...
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REFERENCES [1] Bonnet, P., et al. „Cost minimization analysis to compare activated prothrombin complex concentrate (APCC) and recombinant factor VIIa for haemophilia patients with inhibitors undergoing major orthopaedic surgeries.“ Haemophilia (2009): 1-7. [2] Astermark, J., et al. „A randomized comparison of bypassing agents in hemophilia complicated by an inhibitor: the FEIBA NovoSeven Compar...
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with expanding intracranial bleeds associated with neurologic deterioration, or where urgent surgical intervention is indicated. Often, a single dose of 40 microg/Kg dramatically corrects the coagulopathy in minutes, allowing stabilization of clot expansion and safe neurosurgical intervention, while fresh frozen plasma, vitamin K and other products are administered for subacute maintenance of n...
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6 The objective of this review article was to evaluate the current literature on the increasing off-label use of rFVIIa in the management of critical obstetric hemorrhage. Given the lack of high-level evidence, there is a need to review the clinical indications, observed response and adverse events. This review is designed to aid practitioners in deciding when and how to administer rFVIIa; It m...
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ژورنال
عنوان ژورنال: Journal of Thrombosis and Haemostasis
سال: 2004
ISSN: 1538-7933,1538-7836
DOI: 10.1111/j.1538-7836.2004.01015.x